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And when they stop, the weight comes back a 2025 meta-analysis in The Lancet found that patients who discontinued semaglutide or tirzepatide regained an average of nearly 10 kilograms

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Additionally, liraglutide treatment lowered fasting blood glucose levels in WT mice but not in KO mice (Supplemental Figure 1F

For individuals without diabetes, the main benefit comes from its appetite-suppressing and satiety-enhancing effects

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