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In this report, data have been shown for IR pY1334 only, but the other IR tyrosine phosphorylation site, IR pY1328, gave similar results (data not shown)

Tumour fragments of 3060 mm 3 were grafted into the interscapular fat pad of 8- to 12-week-old female Swiss Nude mice Crl:NU(Ico)-Foxn1nu or CB17/ Icr-Prkdcscid/IcrCrl42-45 purchased from Charles River Laboratories (Les Arbresles, France)