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These effects explain why gastrointestinal side effects are among the most commonly reported adverse reactions to GLP-1 therapy
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When you eat, your intestines release this hormone, which signals to your brain that youre satisfied and slows down how quickly food moves through your stomach
The statistics show that these medications are obviously expensive
Conversely, GLP-1 receptor agonists inhibit AgRP/NPY neurons through a mechanism involving enhanced presynaptic GABAergic input mediated by both TRPC5 and K_ATP channels, and an indirect suppression of excitatory glutamatergic input via polysynaptic circuits [11]
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