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In the central nervous system, GLP-1 primarily originates from preproglucagon (PPG) neurons in the caudal nucleus of the solitary tract

If you also have pain, fever, or difficulty urinating, seek medical attention promptly

However, current evidence does not strongly justify the cessation of GLP-1 RAs based on suicidality concerns

This is especially true if the pain comes on like a lightning bolt rather than building gradually

Another group conducted an RCT and analyzed data from the intervention group consuming a Mediterranean-style diet and identified reduced consumption of processed food as the most impactful component for the improvements in depression observed among this group (124)