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Montano L, Giorgini E, Notarstefano V, Notari T, Ricciardi M, Piscopo M, et al

The circadian clock protein bmal1 is necessary for fertility and proper testosterone production in mice

Interleukin-6 and Cardiovascular Events in Healthy Adults

That said, some patients do report subjective changes in how they feel during the week, particularly regarding appetite suppression and gastrointestinal effects