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Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis

For example, in exploratory trials for Alzheimers disease, a specialized oral formulation of MB (methylthioninium chloride, brand name LMTM) was studied at doses as low as 4 mg twice daily (8 mg total per day) and showed some promise in slowing cognitive decline

These mixed disulphides could be formed either during the oxidation of proteins by GSSG or by the reduction of proteins by GSH

Together with its oxidized partner (GSSG), GSH maintains cellular redox homeostasis 1 , regulates protein functions through S -glutathionylation 2 , contributes to iron-sulfur cluster maturation 3 , and acts as a signalling molecule to directly activate gene expression 4,5

Limitations of the current study, which should also be considered for future studies, include the post hoc nature of the analysis, meaning that assessed outcomes were not prespecified in the original study protocol