One of the crucial elements of ROS regulation and redox state is the production of metabolites, such as glutathione, or the activation of glutathione-associated enzymes
3.1 Biological Interpretation of GSH and GSSG Concentrations A decrease in GSH can result from reduced synthesis, oxidation, conjugation, protein S-glutathionylation, export, degradation, or loss of cellular integrity
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doi:10.1038/ejcn.2017.132 2 Sotgia S, Fois AG, Paliogiannis P, Carru C, Mangoni AA, Zinellu A