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This means the B12 component in a compounded semaglutide formulation is most likely to help patients who are deficient or at risk of deficiency, those eating very little, those following plant-based diets, older adults whose B12 absorption decreases with age, or those with conditions affecting B12 absorption like gastric bypass or certain GI conditions

Conversely, patients who are already close to their glycaemic target may see only modest numerical improvements

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This is unlike the use of supplements, which are usually digested by the stomach acids before they can be absorbed into the bloodstream to reach the skin cells