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The pen delivery is a significant advancement over the creams and serums we previously used. Dr

Examination of the cerebral cortex sections of mice in the vehicle control group revealed characteristic architecture of the mouse cerebral cortex showing multipolar shaped pyramidal cells with rounded vesicular nuclei, granule cells visible as circular shaped neurons with large open-face nuclei, prominent nucleoli, and scanty cytoplasm and small round-vesicular shaped glial neurons interspersed within a pink-staining neuropil

Emerging therapeutic strategies aim to target these pathways specifically like MATs, NOX inhibitors, and Nrf2 activators, though clinical success has been limited by off-target effects and the dual role of ROS in physiological signaling (Pergola et al., 2021)

doi: 10.14283/jpad.2023.55 189

Author Contributions Conceptualization: Pei Shang, Doo-Sup Choi