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This is a significant phenotype, as a similar reduction in circulating triglycerides was not observed with a liver-specific loss of critical lipogenic enzymes, such as fatty acid synthase (FASN) 81

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Other typical agents with reported inhibitory activities on TYR include kojic acid (111,112), methyl gentisate (113,114), ganodermanondiol (71,115), 10-hydroxy-2-decenoic acid (116), Stichopus japonicus extracts (69) and bis (4-hydroxybenzyl)sulphide (117)