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23 , e450e458 (2022)

Given this dilemma, shifting focus to alternative weight loss therapies that do not rely on the leptin-melanocortin system - such as GLP-1 RAs, which have distinctly different mechanisms of action - may offer theoretical feasibility for the treatment of MC4R -deficient obesity

Stimulates Insulin Release When blood glucose levels increase, GLP-1 RAs stimulate the release of insulin

Besides, in the base-case analysis, we assumed a 5-year treatment duration, consistent with other studies (Figure 1)

Average weight loss accelerates to 2 to 4 pounds weekly once you reach your therapeutic dose around week 4