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As a result, KLOW covers a fourth mechanistic dimension that GLOW cannot address: melanocortin-mediated inflammatory resolution

The disease is caused by a mutation in the ATP7B gene, which codes for a protein that facilitates the incorporation of copper into proteins (such as ceruloplasmin) and also the transportation of copper into vesicles that allow it to be secreted in bile.1 The critical effect of a mutation in ATP7B is diminished copper secretion into bile, which leads to excess copper accumulation in the hepatocyte

Work with proper laboratory equipment and protocols according to standard research practices

While its stable at room temperature for several weeks, long term storage requires -20C