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Through activation of the Nrf2antioxidant response element (ARE) signaling axis, GSH upregulates cytoprotective enzymes such as heme oxygenase-1, glutathione peroxidase, and NAD(P)H quinone oxidoreductase-1, thereby enhancing cellular resistance to oxidative injury [10]

They searched for potential open reading frames in human 12S rRNA and found one that could be translated into a 16-amino-acid peptide, which they termed MOTS-c

Unlike the above-mentioned amino acids, ALCAR is not associated with glutathione production

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