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The copper uglies happen because GHK-Cu actively signals skin regeneration, which can temporarily surface underlying issues like clogged pores, low-grade inflammation, or trapped sebum

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Screening phytochemical content, antioxidant, antimicrobial and cytotoxic activities of Catharanthus roseus (L.) G Don stems extract and its fractions

however, no significant interaction was observed, suggesting complementary cardiovascular protection mechanisms (90)

Calabrese V, Ravagna A, Colombrita C, et al