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3 Strategies like enteric coatings to bypass gastric acid, local pH modulation and enzyme inhibitors to deactivate intestinal proteases, muco-penetrating or muco-adhesive carriers, and transient permeation enhancers to increase membrane fluidity are used to mitigate these barriers

Efeitos adversos relatados incluem efeitos gastrointestinais, como indigesto e azia 6

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Drucker et al

Diet + exercise did much better in head to head comparison to metformin