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That step matters because subtle, time-dependent degradation is difficult to detect by eye

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Under normal conditions, when you are in a caloric deficit and muscle protein begins breaking down, the amino acid alanine is released from muscle tissue and converted to glucose in the liver through gluconeogenesis

Despite some minor deviations in aggregate baseline characteristics, including sex, percentage of participants that were Hispanic and percentage of participants with prediabetes at baseline, the study populations were deemed to be sufficiently comparable in terms of treatment effect modifiers (Table 1)

The math is straightforward, but missing it can mean the difference between a gentle starting dose and an aggressive maintenance dose