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Such findings led scientists to label AOD-9604 as the worlds first drug with a metabolic mechanism of action for obesity meaning it works by accelerating fat metabolism rather than suppressing appetite

Common hypotheses point to genetic predisposition plus environmental triggers

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Mechanistic studies have demonstrated that 5(S),15(S)-DiHETE-mediated ferroptosis signalling facilitates the degradation of hypoxia-inducible factor-1 (HIF1)