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Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: Several routes of supplementation and proposal of an original mechanism of action

44 In addition, it is 20.6% in Mexico, 45 17.2% in Niger with 25.0% in male and 13.7% in female, 46 71.6% in French Polynesia, 47 9.9% in Croatia, 40 44.6% in India, 48 28.1% in Jordan, 49 31.8% in sub-Saharan African, 50 10.6% in Thailand with 18.4% in male and 7.8% in female, 51 8.4% in Saudi Arabia 52 and approximately 9.3% in Bangladesh

Research involving animal models suggests that the deletion or modulation of TREK-1 may influence mood-related behaviors, leading to further study into synthetic variants such as PE-22-28

In some embodiments, the otic formulation or composition comprises about 7% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof