Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state
Wolski, W
Those requiring regular or long-term pain relief should discuss alternative options with their healthcare provider to minimise potential gastrointestinal risks
Neural Regen Res 10:13901392 Sutherland BA, Shaw OM, Clarkson AN, Jackson DM, Sammut IA, Appleton I (2005) Neuroprotective effects of ()-epigallocatechin gallate after hypoxia-ischemia-induced brain damage: novel mechanisms of action
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