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As more people use semaglutide, reports of unexpected side effects are growing: unpleasant changes to your skin and body shape, digestive problems, and unexpected fatigue (sometimes called GLP-1 fatigue.) I want to make you aware of these potential problems so you aren't caught off-guard and left holding your stomach and your head...and wondering why you suddenly look old and feel so tired if you opt for a GLP-1 drug

Blood sugar-lowering drugs like insulin or sulfonylureas may increase the risk of hypoglycemia when combined with GLP-1

Rotating your injection site each week may help reduce irritation and keep injections as comfortable as possible

In the JAMA Ophthalmology study, researchers included records of more than 510,000 patients in a national database, about half who were prescribed GLP-1 medication and half who were not