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doi: 10.1186/1475-2891-12-142

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo

It's a new generation sunscreen agent that was specifically designed for high SPF and good UVA protection and based on a 2007 study that compared 18 sunscreen agents available in the EU it really had the best SPF protection (they used the highest concentration allowed by EU regulations from each 18 sunscreens and Trinosorb S gave an SPF 20 all by itself)

A: Yes, it is generally considered very safe for daily use in healthy adults

Acknowledgements We gratefully acknowledge the Breast Cancer Campaign for funding this research