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Mechanistically, E2F1-mediated CHAC1 upregulation promotes PKM2 SUMOylation enabling PKM2 nuclear translocation or kinase activation ( CHAC1s contribution to tumor progression is markedly influenced by the cellular and tumor context, differing across various cancer types

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Il est produit naturellement par le foie et a de multiples fonctions dans lorganisme, agissant comme un puissant dtoxifiant et antioxydant

Materials and methods Post-mortem brain samples