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[Epub ahead of print] Gupta N, Kumar A, Sharma P, et al

"The strength of the association is surprising given the relatively small numbers studied and suggests this increase in metabolic activity is a significant contributor to how these drugs work," said O'Shea

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Notably, this suggests that the hematopoietic response to folic acid in pernicious anemia would not occur if folic acid had been converted to 5-methylTHF in the process of intestinal absorption

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