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CDCA and CA are transformed into secondary BAs and deconjugated by gut microbiota and can either be passively reabsorbed and reenter the circulating BA pool or excreted in feces (Thomas et al., 2008)

These are the kinds of evidence-based approaches that tend to get less attention than a new drug, which is a shame

Unfortunately, anyone who loses weight rapidly will be at risk, but older patients are more prone to having facial changes because of weight loss on GLP-1 receptor agonists

The researchers acknowledged study limitations, including possible outcome misclassification because of the use of diagnostic codes not validated in claims data, potential underrecording of GI adverse events in the claims databases, and not being able to rule out possible residual confounders from certain factors like BMI

This research uncovers a new way that obesity affects cancer and suggests that drugs like Retatrutide could be used to improve cancer treatment in obese patients