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This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse

August 27, 2024

Plant-derived extracellular vesicles as a novel frontier in cancer therapeutics

The authors included two different urolithin A doses (2.5 and 10 mg/kg of body weight) but reported no evidence of a doseresponse effect

Comparing the two relies on separate studies with different designs, endpoints, and eras a structurally weaker basis than a single controlled comparison