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Binding mechanism: Unlike peptides that bind to both the ECD and TMD, small-molecule agonists primarily interact with an allosteric binding site within the TMD

Sources Postpartum Weight Retention Risk Factors and Relationship to Obesity at 1 Year Night-time Sleep Duration and Postpartum Weight Retention in Primiparous Women Association Between Breastfeeding Duration and Postpartum Weight Retention of Lactating Mothers: A Meta-analysis of Cohort Studies Semaglutide - Drugs and Lactation Database (LactMed) Tirzepatide - Drugs and Lactation Database (LactMed) Wilding JPH et al