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2020, pp

doi: 10.1016/j.tim.2021.01.003 6 LagoumintzisGPatrinosGP

Analysis of adverse effects (OR = 0.03, 95% CI: 0.030.09) revealed comparable safety profiles, with reported events primarily consisting of gastrointestinal symptoms (abdominal pain, nausea, reflux, diarrhea, constipation, flatulence, and indigestion), neurological effects (headache and daytime drowsiness), and occasional hypersensitivity reactions or cold sores

Regulatory B cells (Bregs), particularly IL-10producing B10 cells, are decreased or functionally impaired in HT, diminishing control over pro-inflammatory T cell activity (Stafford, EA

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