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Alves FD, Lane TPM, Nguyen AI, Bush S, Ayton

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No evidence of carcinogenicity was observed in male or female mice

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The mechanism underlying the anti-inflammatory properties of SGLT-2i could be a downstream effect of its ability to lower uric acid and insulin production [97]

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Another natural compound, trigonelline, a methylated form of nicotinic acid, is a newly discovered NAD + precursor able to increase NAD + in multiple species, with preclinical implications for use in sarcopenia, and for muscle and cognitive decline in aging 124,130,131

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What this means: The Committees recommendation is advisory only

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