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These drugs are FDA-approved for type 2 diabetes and obesity, but growing evidence supports their use for rheumatoid arthritis, psoriatic arthritis, lupus, osteoarthritis, and metabolic/autoimmune diseases. Who should not take GLP-1 medications

In cardiovascular disease , studies have found these medications provide cardiovascular protection, with a 1420% reduction in major adverse cardiovascular events (MACE), a benefit understood to be at least partially mediated by anti-inflammatory pathways rather than glycemic control alone

However, it can be very effective for many

The pathway most highly enriched following RYGB was cholesterol import, which was markedly upregulated