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Semaglutide (aka Ozempic or Wegovy) has become ubiquitous because of established benefits in diabetes and obesity but SELECT showed that the drug should be considered in those who are obese with established atherosclerotic CV disease (ASCVD.) In March of 2024 the FDA approved a new indication for Wegovy based on the SELECT trial to reduce the risk of CV death, stroke, and heart attack in adults with cardiovascular disease and either obese or overweight My Thoughts on Semaglutide for Secondary Prevention After looking in detail at SELECT I realized that it does not apply to most patients in my practice

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This mechanistic depth is the basis for Phase 2 outcomes that exceeded all prior single- or dual-agonist research

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Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease