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Hypoxia-like tissue injury as a component of multiple sclerosis lesions

Mechanistically, SYVN1 binds to HMGB1, promoting its ubiquitination and degradation and alleviating SCIRI in rats by downregulating HMGB1 and activating the Nrf2/HO-1 pathway

doi: 10.3389/fgstr.2026.1790420 Received 18 January 2026 Revised 18 April 2026 Accepted 27 April 2026 Published 18 May 2026 Volume 5 - 2026 Edited by Glen A