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One study found the cost of weight loss per kilogram associated with orlistat was US$546, with a cost of US$71,000 per quality-adjusted life year (QALY) in Europe [13]

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Pregnant and those who are breastfeeding are not suitable for this treatment and for people under the age of 18

According to Shuja et al 11 study, risk factors for melasma other than GSH, there was also a decrease in levels of other antioxidants such as superoxide dismutase (SOD), catalase, vitamin E, and vitamin C which were statistically significant in melasma subjects compared to controls

Athletes use B12 injections for performance recovery, while older adults benefit from prevention of age-related cognitive decline