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Those at a higher risk for developing a deficiency in Vitamin B12 levels include older adults, people with pernicious anemia, people with low stomach acid, people with malabsorption problems due to digestive problems such as IBS, gastritis, Colitis and Crohns (Ref) and certain medications

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A study has demonstrated that GPX4 inhibition can simultaneously activate the caspase-8-mediated apoptotic pathway and ferroptosis, suggesting shared upstream signaling mechanisms (143)