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Gehlsen KR, Hadley ME, Levine N, Ray CG, Hendrix MJC
Consistency often matters more than intensity
Increasing sodium and fluid intake, avoiding rapid position changes (especially getting out of bed quickly), and wearing compression stockings can help maintain adequate blood volume and pressure
Specifically, methylene tetrahydrofolate (THF) dehydrogenases catalyze the oxidation of 5,10-methylene-THF to form 10-formyl-THF, which is subsequently oxidized to CO 2 with concomitant NADPH production by 10-formyl-THF dehydrogenases (55)
If targets are not achieved, additional RAI should be added at one and then two other mealtimes (basal-bolus) as required, with titration as for the initial RAI [2, 3, 18]
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