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Paracetamol (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis

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doi: 10.1016/j.bbadis.2019.165579, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 51

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