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Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

Consistent with this observation, glutamine starvation has been associated with impaired uptake of cystine through xCT and decreased intracellular glutathione levels 62

Furthermore, while 4-HNE promotes cyst growth via multiple kinase pathways (270), the hierarchical integration of these pathways (e.g., which is the rate-limiting step) and their crosstalk with ferroptosis core networks (e.g., lipid peroxidation amplification) are poorly defined

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.McDonald J.E., Kiland J.A., Kaufman P.L., Bentley E., Ellinwood N.M., McLellan G.J