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In 2022, the United States is leading the largest market share over the forecast period

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Other research, including a 2025 study published in Nature Medicine , has explored potential links between GLP-1 use and lower risks of conditions such as substance use disorders and dementia

Based on data from Phase 2 clinical trials including the pivotal randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) the most frequently reported sensations and side effects with retatrutide are largely gastrointestinal (GI) in nature

These side effects are usually temporary and subside over time