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While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function

To address this, we conducted a systematic review and network meta-analysis (NMA) examining RCTs of patients with T2D and ASCVD or high CV risk, with two primary objectives: (1) To perform a class-level NMA to evaluate the effect of tirzepatide compared with placebo on cardiovascular outcomes

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Lipo B's mechanism centers on lipotropic agents (methionine, inositol, choline) that facilitate the breakdown and transport of fat from the liver

Information on plant phytochemicals, therapeutic uses, and both common and botanical names of plants was compiled from these databases and incorporated into the review