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It would be worthwhile to solicit Osler himself for his thoughts on this matter, though his response might be that each and every one of us is unique, because what is deficient in one person might not be in another

In the case of metastatic breast cancer, combining ipilimumab and nivolumab with anthracycline-based chemotherapy leads to an escalation in toxic side effects without yielding any clinical benefits

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Mutant mice were born with red, shiny skin that rapidly dried and died, lacking typical ichthyosiform lesions (Moran et al., 2007)

The same eating habits that produced early weight loss may no longer create the same calorie deficit