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[1] [2] As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, Mounjaro works by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite

Either route provides sustained GLP-1 receptor activation, which is why appetite suppression tends to strengthen over weeks, not hours

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A small 2024 pilot study examining tirzepatide (a dual GIP/GLP-1 agonist) showed similar trends, with participants reporting lower withdrawal symptom severity during quit attempts