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For example, alcohol causes the malfunctioning of biological signalling molecules by increasing the amount of ROS, while decreasing the levels of cellular antioxidants (267), leading to the accumulation of acetaldehyde (268) and causing cell apoptosis as a result of it inducing mitochondrial dysfunction (269)

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Proper medical diagnosis is essential before treatment, as not all nerve pain stems from B12 deficiencydiabetes, autoimmune disorders, and other conditions cause similar symptoms

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Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion

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