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The opioid receptor hypothesis A separate line of work proposed that DSIP possesses agonist activity at opiate receptors a hypothesis explicit in the title of the principal human withdrawal paper, which describes DSIP as a neuropeptide with potential agonistic activity on opiate receptors. [13] Supporting animal evidence came from Scherschlichts group, where DSIP at 25.5 mcg/kg IV attenuated naloxone-precipitated withdrawal jumping in morphine-dependent mice

Some rodent studies found that exenatide reduced oxycodone self-administration and heroin-seeking behaviors, while others reported minimal effects on morphine-related behaviors

Plasma is generally preferred for consistency and cardiovascular relevance

The generic anti-obesity drugs are cost-saving (naltrexone-bupropion) or cost-effective (phentermine-topiramate)