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If more than 3 days have passed since the missed dose, skip it entirely and take the next scheduled dose on your regular day

D.Villanueva PazM.et al (2015)

It inhibits the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12), modulates the polarization of macrophages towards the M2 (anti-inflammatory) phenotype, and stimulates collagen production in models of pulmonary and cutaneous fibrosis

But if your B12 is high without supplementation , it can be a marker for underlying conditions that require medical evaluation, including liver disease, kidney dysfunction, and certain cancers

It is also not a replacement for foundational nutrition and training, it amplifies what good habits already deliver