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GEMM studies used both male and female mice induced at 810 weeks old, but xenograft studies used only females, transplanted at 8 weeks old

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They postulated an anti-inflammatory mechanism, quoting previous similar findings in animal trials [97, 98], by directly inhibiting TNF- induced NF-B resulting in reduction of proinflammatory markers, including IL-6, and also reducing nitric oxide species and reactive oxygen species while reversing eosinophilic infiltration into the lung tissues