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Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production

Klocke B, Krone K, Tornes J, Moore C, Ott H, Pitychoutis PM (2023) Insights into the role of intracellular calcium signaling in the neurobiology of neurodevelopmental disorders

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PMID: 1675986

Thus, we may hypothesize that by upregulating melatonin expression with the help of peptides like MT-1, there may be a notable reduction in neuroinflammation levels