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Overexpression of phospholipid - hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation - induced expression of interstitial collagenase/matrix metalloproteinase - 1 by suppression of phosphatidylcholine hydroperoxide - mediated NFkappaB activation and interleukin-6 release

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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

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J Periodontal Res 51:8694 Wong BKJ, McGregor NR, Butt HL, Knight R, Liu LY, Darby IB (2016) Association of clinical parameters with periodontal bacterial haemolytic activity