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For HS patients using a GLP-1 RA for six months, the researchers found: Less severe HS: 54% of participants improved by one point and 12% improved by two or more points on the HS-PGA (Hidradenitis Suppurativa Physician Global Assessment) scale, which measures general severity of HS on a scale from 0 to 5

They also approach the same general system from different angles

(38) reported microglia and astrocytes overactivation, increase in proinflammatory cytokines, mitochondrial dysfunction, and abnormal neuronal morphology in the hippocampus of young and old mice subjected to 24 h of sleep deprivation, whereas treatment with urolithin A protected against these adverse effects

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