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Challenges and Gaps in Research While estrogen-based therapies, such as HRT and SERMs, have demonstrated significant benefits in managing menopausal mental health issues, their use is not without significant challenges and controversies

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As of the publication date of this article, announcements regarding potential reclassification have been made but no formal FDA regulatory action has been finalized

756 , 763 For more information on barriers to cognitive assessment in primary care where most dementia diagnosis and management occurs and potential solutions, see the Special Report from 2019 Alzheimer's Disease Facts and Figures

Below, we outline experimental pharmacologic therapies by physiologic trait