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She said those include: Well-designed, randomized, placebo-controlled human clinical trials for specific diagnoses (ACL tears, cartilage injuries, muscle injuries, rotator cuff tears, and so on)

The safest approach is to assume detection windows longer than published estimates

further showed that decision-making behavior in chronic pain patients exhibits significantly heightened sensitivity to punishment, with posterior insular activity strongly correlated with fatigue and pain ratings, providing direct evidence of the link between reward system dysfunction and interoceptive dysregulation (183)