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Additional funding for this project was provided by M3 Biotechnology, Inc

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The numbered markings typically show 10, 20, 30, 40, 50, 60, 70, 80, 90, 100

The Importance of Receptor Trafficking in Biased GLP-1R Agonism The endocytic trafficking effects of a number of biased GLP-1RAs have been reported (87, 111)

This may be related to gender-related pharmacokinetic differences (lower clearance of GLP-1RA in females) 41 and postmenopausal changes in gastrointestinal motility 42